Our collaboration with the MassGeneral Institute for Neurodegenerative Disease advanced the development of the Multiple Sclerosis Discovery Forum website. We intend for this online research community to have a powerful impact on the generation of novel hypotheses that will shape future studies in MS. We believe the site will catalyze connections across disciplines that will help accelerate us toward a cure. ACP is a founding member of the Orion Bionetworks, a multi-institution cooperative alliance, that is unlocking the power of shared data and predictive modeling to help transform our understanding of diseases such as multiple sclerosis (MS) and accelerate the search for cures. The launch of the ACP Clinical Effectiveness Study Network also promises substantial future impact. This network brings together our ACP Repository clinical sites into an organized group focused on designing and conducting important clinical research in MS and other related disorders.