New imaging technique shows demyelination
Submitted by Scott on Mon, 2007-07-02 05:47.
Researchers have recorded how myelin degrades real-time in live mice using a new imaging technique called CARS. Using a technique called coherent anti-Stokes Raman scattering microscopy, or CARS, scientists injected a compound called lysophosphatidylcholine (LPC) into the myelin of a mouse. Then, using CARS, they observed an influx of calcium ions into the myelin. This influx is now believed to start the process of myelin degradation.


Journal Article
The journal article is at the Journal of Neuroscience Research.
Demyelination
The calcium ion influx is the same process that occurs from glutamic neurotoxicity. Perhaps there is a process where neurochemicals are providing assistance to the disease process in MS.
Does this imply that calcium
Does this imply that calcium supplementation is a "bad thing" for MSers? Oddly enough fish oils, calcium, and d3 are the 3 supplements that even the Rocky Mtn MS Center says have some scientific evidence that implies helpfulness.
Calcium supplementation
Calcium supplements (and their effects) are something different when talking about calcium ion channels. Ion channels are little pores that open and close at the molecular level on the membranes of cells, depending on the "cell potential" (controlling the electrochemical voltage of the cell). And, there are several different types (i.e. sodium, potassium, calcium, etc). They direct certain molecular particles, that have a specific purpose (usually involving transportation of electrical signals, like in the brain, peripheral nervous system and heart). When there is neurotoxicity (sometimes also referred to as cytotoxicity), there is an inordinate, and inappropriate, influx of calcium IONS - little molecular sized particles of calcium that are directed through the channels in the wrong direction, or at a severely increased rate (also called "upregulation") because of mixed up chemical signals at the molecular level that leave the channels open instead of closing when the appropriate "cell potential" is reached. Exactly WHAT mixed up signals . . . no one knows for certain yet. But, rest assured, the supplements are still important as a daily regimen. Especially the calcium and vitamin D if you are taking steroids (which can facilitate leading to osteoporosis). So, taking more calcium won't cause more calcium to build up in the neurons, any more than eating more vegetables will turn you into a salad. They aren't related that way.
There is still a big argument in the scientific community about vitamins and antioxidants, about whether or not they really work. Well . . . on the side of caution, since most have been proven to be fairly safe to take, then what's the harm. Except a little less in the wallet.