Clinical Trial of LDN for MS Has Begun in Italy
Submitted by art on Wed, 2006-12-27 07:09.
A long-awaited pilot study of low dose naltrexone therapy in multiple sclerosis has been implemented by the Milan neurological researcher, Dr. Maira Gironi. Several northern Italian hospitals began enrolling patients for the study during the first week of December. Dr. Gironi anticipates that the 6 months of LDN treatment will have been completed by early summer. Importantly, Dr. Gironi’s research team has long been a locus for significant research on endorphins in relation to illness, and this study will track accurate assessments of the patients’ beta-endorphin levels in response to their LDN treatment.
What?
Re:What?
LDN and NK cells
LDN and NK cells
Re:LDN and NK cells
Go to the ldn website for more information: http://www.ldninfo.org
Clinical Trial of LDN
To anon, 27.12.06
I have experience collecting health success stories related to patients undertaking Low Dose Naltrexone (LDN) treatment under the accepted protocol (ldninfo.org). I have also intermittently followed the course of the LDN discussion group for some time.
Perhaps my personal experience may assist.
From my observational experience, a percentage of patients do experience some minimal side effects.
A high percentage experience an early side effect of sleep disruption which can be managed. Equally, a percentage seem to experience early benefit of increased bladder control.
Apart from early side effects or benefits, some report LDN can re-awaken old symptoms - and sometimes this re-awakening of old symptoms will occur periodically over years. An old symptom re-awakens, then resolves and a different old symptom may re-awaken and resolve. For those for whom this has occurred, once the symptom has resolved, the symptom has not returned. Others do not report experiencing any re-awakening of old symptoms.
Some attest they were not worried by these symptom re-awakenings and so continued treatment - others with perhaps less resolve were worried and discontinued treatment.
Of those who persevered - for at least 6 months and many for years now, they attest to halting or dramatic slowing of disease progression.
This is a simple observational statement that is not supported by any measurable evidence, however; there are many LDN success stories. It is very important for LDN to become recognized as a treatment option for MS or any other auto-immune related diseases - so I'm pleased to learn of a new study involving LDN - and I can only hope the accepted LDN protocol is stringently applied.
I'm curious about
' ... AHCC[ active hexose correlated compound], an effective and safe booster of NK cells to kill cancer and some viruses, has not been tested or recommended for MS. ... ';
could you please elaborate on your personal experience or if you know of any successes.
Thanks,
Cris
Antibiotics & Antimicrobials - QUINOLONES & FLUOROQUINOLONES
Antibiotics & Antimicrobials - QUINOLONES & FLUOROQUINOLONES - linked to tendinopathies (pain, stiffness, loss of strength - mainly Achille tendon but also shoulders, knees, hand, and plantar fascia) and, less often, arthralgia (joint pain) and myalgia (muscle pain) - tendons and muscles are soft tissue - sensory nerve endings in tendons signal to brain areas that process touch and motor control and vice versa.
Risk factors are older age, corticosteroid therapy and renal dysfunction
FLUOROQUINOLONES & QUINOLONES - EXAMPLES:
Fluoroquinolones:
Ciprofloxacin, Enoxacin, Fleroxacin, Gatifloxacin, Gemifloxacin, Grepafloxacin, Levofloxacin, Lomefloxacin,
Moxifloxacin, Norfloxacin, Ofloxacin, Pefloxacin, Prulifloxacin, Rufloxacin, Sparfloxacin, Temafloxacin,
Trovafloxacin, Sitafloxacin
Other Quinolones:
Cinoxacin, Flumequine, Nalidixic acid, Oxolinic acid, Pipemidic acid, Piromidic acid, Rosoxacin
.....
Fluoroquinolones antimicrobial agents are widely used in clinical practice as broad-spectrum antimicrobials with excellent bioavailability. However, they have been reported to induce tendinopathies and, less often, arthralgia and myalgia (Jorgensen et al., 1991; Hayem and Carbon, 1995; Stahlmann and Lode, 2000; Stahlmann, 2002). The main target is the Achilles tendon, where complete rupture can occur; other sites of involvement include the shoulders, knees, hand, and plantar fascia.
More than 400 cases of FQ-induced tendinopathy have
been reported (Ribard et al., 1992; Zabraniecki et al., 1996; Lewis et al., 1999; Van Der Linden et al., 2001).
Risk factors for fluoroquinolones-induced tendinopathy include older age, corticosteroid therapy and renal
dysfunction. Achilles cause prolonged functional impairment. This pathology can be observed in patients only a few hours or days after receiving a single oral dose of FQ, and results in a serious source of invalidity
(Stahlmann and Lode, 2000).
Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on October 20, 2003; DOI: 10.1124/jpet.103.057984
0022-3565/04/3081-394-402$20.00
JPET 308:394-402, 2004
TOXICOLOGY
In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress, F. Pouzaud, K. Bernard-Beaubois, M. Thevenin, J.-M. Warnet, G. Hayem, and P. Rat
Received July 31, 2003; accepted September 30, 2003.
http://jpet.aspetjournals.org/cgi/content/full/308/1/394
New MS Study linking Prolactin during pregnancy to mylin repair
Hi Everyone
I am excited to see a study done in Calgary and posted on mssociety.ca that says that the reason MS is in remission during pregnancy is because its due to prolactin prodcution that repairs myelin. Is it possible that LDN which increases the levels of endorphins also increases the levels of prolactins and that is why it helps MS. I would really be interested to see if anyone is follwoing this chain of thought.
Please let me know
All the best
Tabassum
in Dubai
ldn/copaxone both not helpful..........but tamiflu does.
I have stopped taking ldn because it didn't seem to help. I always have a small attack at the end of spring and a large one when fall hits. Nothing changes that pattern. The rest of the time my MS in not really progressive. I basically have stopped Copaxone after years too. I have resolved neither works for me. 20 yrs of MS still kind of walking and that is that. Don't see why I should bother with pills or injections for not.
But interestingly I noticed when on Tamiflu for the flu my legs were looser and fatigue much much less. I am experimenting now with tamiflu without the flu to see how it makes me feel. So far on second day I feel completely normal energy wise like a health normal person. Pretty incredible. Tough on stomach though, so i am taking one after dinner at night. Viva experimentation! :)
Ric