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Crohn's Naltrexone Pilot Shows Effect

Submitted by art on Thu, 2006-06-01 06:18.

A Penn State College of Medicine pilot study suggests that a drug used to ease symptoms of alcohol and drug addiction (naltrexone) may also bring relief to people with Crohn's disease.

In the study, people with diagnosed Crohn's disease were treated with a low dose of naltrexone (LDN), an FDA-approved drug used to ease symptoms of withdrawal from substance abuse, and monitored for improvement of symptoms for 12 weeks. Quality of life surveys were given every four weeks for 16 weeks.

The results showed that 89 percent of participants showed an improvement with therapy, while 67 percent achieved remission of symptoms. The only side effect to treatment was sleep disturbance in some patients.

LDN is used by some people with MS with many anecdotal reports of benefit. We'd love to see an MS trial with LDN take place.

brainfreeze's picture

LDN's rose coloured glasses.

Submitted by brainfreeze on Tue, 2006-07-18 14:02.
I took ldn for my ms and found it to be great for my cognitive impairment,fatigue, balance and endurance. Trouble was I also experienced mood swings that lead to depression. No matter where I went for help I was told "oh no our ldn does not cause this", in fact it causes the opposite. I had spoken with 6 online friends that experienced depression and or mood swings. I have some other online friends with chrons. I run a chronic illness support group. While I would love to pass on how well this is doing with chrons, I'm afraid to put anyone else through this. I cringe when I think of autistic children going through this. A study would help with the side effects and is this normal? It just seemed like those in the know, were so busy keeping their ldn reputation up, that they did listen to those of us that were having problems. Looking at ldn through rose coloured glasses. Now I am searching for the probability of lymes. After all LDN does not cause progression. *foot note* I went off the LDN and had an awful flare. Depression big time, Gait ataxia, Speech ataxia, trouble swallowing, dizziness, crying jags that would not stop.
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I saw Dr. Smith's presentation....

Submitted by Scott on Thu, 2006-06-01 09:02.
At the LDN conference in Bethesda in April. The presentation was very impressive. Video of her complete presentation is available here.
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