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Biochemical Evidence of Gray Matter Involvement in MS

Submitted by art on Mon, 2005-10-03 07:18.

A study of MS brains versus healthy control brains concludes that both normal appearing white matter (NAWM) and gray matter (NAGM) from MS brains contain considerable biochemical alterations. The involvement of GM in MS was also supported by the decrease in the levels of neurofilament light protein in all the specimens analyzed.

The more we look at actual human specimens, the more we seem to find is going on in this disease.

Julie Morgenlender's picture

A great descriptive article on gray matter in MS

Submitted by Julie Morgenlender on Mon, 2005-10-03 12:13.
To find out more about what gray matter is and how it compares to white matter in terms of involvement in MS, check out Hollie Schmidt's article in the Accelerated Cure Project Fall 2005 newsletter here (http://www.acceleratedcure.org/downloads/index.ph p).

For those on the mailing list, paper copies will be sent out this week. If you are not on the mailing list but would like to be, go to www.acceleratedcure.org and click the "Sign Up" button at the top of each page.
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Re:A great descriptive article on gray matter in M

Submitted by Bromley on Tue, 2005-10-04 09:10.
Hollie's article was interesting but really hammered home the fact that this disease is much grimmer than first imagined. When I was dx (18 months ago) the neuro just mentioned demyelination in terms of axons etc. Now we read that we are also losing grey matter (neurones). I would dispute the term 'a great descriptive article on gray matter in MS' and rephrase it 'a grim descriptive article on gray matter in MS'. For someone with MS, knowing that your brain and/or spinal cord is being eaten away / dying off, 'great' is the last term that comes to mind.
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Research

Submitted by Bromley on Mon, 2005-10-03 07:33.
There seems to be a limitless supply of research papers that just observe things e.g. we looked at this aspect of an MS brain and found XXX. Why can't the researchers go beyond obervations e.g. we found XXX was elevated in MS brains, this was because of XXX, the following therapeutic strategies should prevent this happening? Art, I'm looking forward to hearing about the ECTRIMS / ACTRIMS conference. From the press coverage I saw it appeared to be a PR exercise by the drugs companies rather than any scientific breakthroughs by the research community.
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